Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages.

@article{Murakami2006SignalingOV,
  title={Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages.},
  author={Masato Murakami and Shinobu Iwai and Sachie Hiratsuka and Mai Yamauchi and Kazuhide Nakamura and Yoichiro Iwakura and Masabumi Shibuya},
  journal={Blood},
  year={2006},
  volume={108 6},
  pages={1849-56}
}
Vascular endothelial growth factor (VEGF) and VEGF receptor-1 (VEGFR-1/Flt-1) were shown to be involved in pathological angiogenesis, particularly rheumatoid arthritis (RA). However, the molecular basis of their actions is not fully understood. Here we report that in a murine model of RA, deletion of the tyrosine kinase (TK) domain of VEGFR-1 decreased the… CONTINUE READING