Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.

@article{Tunduguru2014SignalingOT,
  title={Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.},
  author={Ragadeepthi Tunduguru and Tim Ting Chiu and Latha Ramalingam and Jeffrey S. Elmendorf and Amira Klip and Debbie C Thurmond},
  journal={Biochemical pharmacology},
  year={2014},
  volume={92 2},
  pages={380-8}
}
Skeletal muscle accounts for ∼ 80% of postprandial glucose clearance, and skeletal muscle glucose clearance is crucial for maintaining insulin sensitivity and euglycemia. Insulin-stimulated glucose clearance/uptake entails recruitment of glucose transporter 4 (GLUT4) to the plasma membrane (PM) in a process that requires cortical F-actin remodeling; this process is dysregulated in Type 2 Diabetes. Recent studies have implicated PAK1 as a required element in GLUT4 recruitment in mouse skeletal… CONTINUE READING