Signaling of the Tissue Factor Coagulation Pathway in Angiogenesis and Cancer

  title={Signaling of the Tissue Factor Coagulation Pathway in Angiogenesis and Cancer},
  author={M. Belting and J. Ahamed and W. Ruf},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  • M. Belting, J. Ahamed, W. Ruf
  • Published 2005
  • Biology, Medicine
  • Arteriosclerosis, Thrombosis, and Vascular Biology
  • Activation of coagulation precedes or coincides with angiogenesis in wound healing and postischemic tissue regeneration. Advanced cancer is associated with a hypercoagulable state, and tissue factor expression by cancer cells has received widespread attention because of its significant contribution to the pathogenesis of cancer progression and metastasis. Our recent work demonstrates that tissue factor–mediated cellular signaling is relevant to cancer angiogenesis. Here we review the molecular… CONTINUE READING
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    • 96
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    • Thrombosis research
    • 2007
    • 34
    Tissue factor in cancer progression and angiogenesis.
    • 89
    Tissue factor and PAR2 signaling in the tumor microenvironment.
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    • 75
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    • 7
    • PDF
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    • 38


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    • 135
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    • 330
    • PDF
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    • 1999
    • 318
    • PDF
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