Signaling of c-kit in dendritic cells influences adaptive immunity.

  title={Signaling of c-kit in dendritic cells influences adaptive immunity.},
  author={Prabir Ray and Nandini Krishnamoorthy and Timothy Oriss and Anuradha Ray},
  journal={Annals of the New York Academy of Sciences},
The binding of the receptor tyrosine kinase, c-kit, to its ligand, stem cell factor (SCF), mediates numerous biological functions. Important roles for c-kit in hematopoiesis, melanogenesis, erythropoiesis, spermatogenesis, and carcinogenesis are well documented. Similarly, activation of granulocytes, mast cells, and of eosinophils in particular, by c-kit ligation has long been known to result in degranulation with concomitant release of pro-inflammatory mediators, including cytokines. However… CONTINUE READING


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