Signaling of Reactive Oxygen and Nitrogen Species in Diabetes Mellitus

@inproceedings{Afanasev2010SignalingOR,
  title={Signaling of Reactive Oxygen and Nitrogen Species in Diabetes Mellitus},
  author={Igor B Afanas'ev},
  booktitle={Oxidative medicine and cellular longevity},
  year={2010}
}
Disorder of physiological signaling functions of reactive oxygen species (ROS) superoxide and hydrogen peroxide and reactive nitrogen species (RNS) nitric oxide and peroxynitrite is an important feature of diabetes mellitus type 1 and type 2. It is now known that hyperglycemic conditions of cells are associated with the enhanced levels of ROS mainly generated by mitochondria and NADPH oxidase. It has been established that ROS stimulate many enzymatic cascades under normal physiological… CONTINUE READING