Signaling of Macrophage Inflammatory Protein (MIP)-3β Facilitates Dengue Virus-Induced Microglial Cell Migration

@article{Jhan2018SignalingOM,
  title={Signaling of Macrophage Inflammatory Protein (MIP)-3$\beta$ Facilitates Dengue Virus-Induced Microglial Cell Migration},
  author={Ming-Kai Jhan and T. Shen and Po-Chun Tseng and Yung-Ting Wang and Chiou-Feng Lin},
  journal={Viruses},
  year={2018},
  volume={10}
}
The infection by dengue virus (DENV) of microglia causes cell activation and migration via a mechanism involving viral entry, RNA release, and Toll-like receptor 3 signaling. In this study, we demonstrated that secreted chemotactic factors present in microglial conditioned medium (MCM) facilitated cell motility in the murine BV2 microglial cells. The pharmacological disruption of lipid rafts/caveolae reduced DENV- and ultraviolet (UV)-inactivated MCM-induced microglial cell migration. An… Expand

References

SHOWING 1-10 OF 29 REFERENCES
Dengue virus infection increases microglial cell migration
Dengue virus infection induces interferon-lambda1 to facilitate cell migration
CCR7-mediated c-Jun N-terminal kinase activation regulates cell migration in mature dendritic cells.
Novel evidence of microglial immune response in impairment of Dengue infection of CNS.
Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus
Microglia retard dengue virus-induced acute viral encephalitis
Anti‐TNF‐α restricts dengue virus‐induced neuropathy
Microglia-mediated neuroinflammation is an amplifier of virus-induced neuropathology
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