Signaling mechanisms that regulate actin-based motility processes in the nervous system.

@article{Meyer2002SignalingMT,
  title={Signaling mechanisms that regulate actin-based motility processes in the nervous system.},
  author={Gary E Meyer and Eva L. Feldman},
  journal={Journal of neurochemistry},
  year={2002},
  volume={83 3},
  pages={490-503}
}
Actin-based motility is critical for nervous system development. Both the migration of neurons and the extension of neurites require organized actin polymerization to push the cell membrane forward. Numerous extracellular stimulants of motility and axon guidance cues regulate actin-based motility through the rho GTPases (rho, rac, and cdc42). The rho GTPases reorganize the actin cytoskeleton, leading to stress fiber, filopodium, or lamellipodium formation. The activity of the rho GTPases is… CONTINUE READING
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International Society for Neurochemistry

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