Signaling mechanisms that regulate actin-based motility processes in the nervous system.

  title={Signaling mechanisms that regulate actin-based motility processes in the nervous system.},
  author={Gary E Meyer and Eva L. Feldman},
  journal={Journal of neurochemistry},
  volume={83 3},
Actin-based motility is critical for nervous system development. Both the migration of neurons and the extension of neurites require organized actin polymerization to push the cell membrane forward. Numerous extracellular stimulants of motility and axon guidance cues regulate actin-based motility through the rho GTPases (rho, rac, and cdc42). The rho GTPases reorganize the actin cytoskeleton, leading to stress fiber, filopodium, or lamellipodium formation. The activity of the rho GTPases is… CONTINUE READING
66 Citations
136 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 66 extracted citations


Publications referenced by this paper.
Showing 1-10 of 136 references

Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility

  • C. Egile, T P.Loisel, +4 authors M F.Carlier
  • J. Cell Biol
  • 1999
Highly Influential
3 Excerpts

International Society for Neurochemistry

  • G. Meyer, E. L. Feldman
  • Journal of Neurochemistry,
  • 2002

Similar Papers

Loading similar papers…