Signaling mechanisms of metabotropic glutamate receptor 5 subtype and its endogenous role in a locomotor network.

@article{Kettunen2002SignalingMO,
  title={Signaling mechanisms of metabotropic glutamate receptor 5 subtype and its endogenous role in a locomotor network.},
  author={Petronella Kettunen and Patrik Krieger and Dietmar Hess and Abdeljabbar El Manira},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 5},
  pages={
          1868-73
        }
}
Metabotropic glutamate receptors (mGluRs) act as modulators in the CNS of vertebrates, but their role in motor pattern generation in particular is primarily unknown. The intracellular signaling mechanisms of the group I mGluRs (mGluR1 and mGluR5), and their endogenous role in regulating locomotor pattern generation have been investigated in the spinal cord of the lamprey. Application of the group I mGluR agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG) produced oscillations of the intracellular… CONTINUE READING

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