Signaling mechanisms of angiotensin II in regulating vascular senescence

  title={Signaling mechanisms of angiotensin II in regulating vascular senescence},
  author={Li-juan Min and Masaki Mogi and Masaru Iwai and Masatsugu Horiuchi},
  journal={Ageing Research Reviews},
Angiotensin (Ang) II, the major effector of the rennin-angiotensin-aldosterone system (RAAS), has multiple functions in regulating cardiovascular hemodynamics and structure. Recent evidence strongly supports that Ang II promotes the onset and progression of vascular senescence, which is associated with vascular functional and structural changes, contributing to age-related vascular diseases. The vast majority of the cardiovascular actions of Ang II, including vascular senescence, are mediated… CONTINUE READING


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