Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy

@inproceedings{Aziz2013SignalingMO,
  title={Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy},
  author={Mohammed Talaat Abdel Aziz and Ibrahim Naguib El Ibrashy and Dimitri P. Mikhailidis and Ameen Mahmoud Rezq and Mohamed Abdel Aziz Wassef and Hanan Hassan Fouad and Hanan Hosni Ahmed and Dina A Sabry and Heba Mohamed Shawky and Rania Elsayed Hussein},
  booktitle={Diabetology & metabolic syndrome},
  year={2013}
}
BACKGROUND Curcumin exhibits anti-diabetic activities, induces heme-oxygenase-1 (HO-1) and is an inhibitor of transcriptional co-activator p300. A novel water soluble curcumin derivative (NCD) has been developed to overcome low invivo bioavailability of curcumin. We evaluated the effect of the NCD on signaling mechanisms involved in cardiomyocyte hypertrophy and studied whether its action is mediated via inducible HO-1. MATERIALS AND METHODS Rats were divided into controls, controls receiving… CONTINUE READING

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NCD and curcumin decreased plasma glucose , GHb and increased insulin levels significantly in diabetic rats .
NCD and curcumin decreased plasma glucose , GHb and increased insulin levels significantly in diabetic rats .
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