Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord.


Activation of muscarinic acetylcholine receptors (mAChRs) inhibits spinal nociceptive transmission by potentiation of GABAergic tone through M(2), M(3), and M(4) subtypes. To study the signaling mechanisms involved in this unique mAChR action, GABAergic spontaneous inhibitory postsynaptic currents (sIPSCs) of lamina II neurons were recorded using whole-cell… (More)
DOI: 10.1016/j.neuroscience.2008.11.039