Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide.

@article{Krueger2010SignalingMI,
  title={Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide.},
  author={Dagmar Krueger and Martin Foerster and Kerstin Mueller and Florian Zeller and Julia Slotta-Huspenina and Jemma Donovan and David Grundy and Michael Schemann},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2010},
  volume={22 11},
  pages={
          1224-31, e319-20
        }
}
BACKGROUND H(2) S actions in the gut involve neural activation. This study aimed to reveal the signaling mechanisms responsible for the pro-secretory effect of H(2) S by using TRPV1 and unselective TRP blockers and inhibitors of other signaling cascades hitherto described to be targeted by H(2) S elsewhere. METHODS Ussing chamber voltage clamp technique was used to study actions of the H(2) S donor NaHS on secretion in guinea-pig and human colon. NaHS effects on guinea-pig primary afferents… CONTINUE READING
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