Signaling mechanisms inducing hypo-responsiveness of phagocytes during systemic inflammation.

@article{Freise2019SignalingMI,
  title={Signaling mechanisms inducing hypo-responsiveness of phagocytes during systemic inflammation.},
  author={Nicole Freise and Alina Burghard and Theresa Ortkras and Niklas Daber and Achmet Imam Chasan and Saskia-L. Jauch and Olesja Fehler and Julia Hillebrand and Mosab Schakaki and Jessica Rojas and Bodo Grimbacher and Thomas Vogl and Andreas Hoffmeier and Sven Martens and Johannes Roth and Judith Austermann},
  journal={Blood},
  year={2019}
}
The inflammatory responsiveness of phagocytes to exogenous and endogenous stimuli is tightly regulated. This regulation plays an important role in systemic inflammatory response syndromes (SIRS). In SIRS phagocytes initially develop a hyper-inflammatory response followed by a secondary state of hypo-responsiveness, a so called tolerance. This hypo-responsiveness can be induced by endotoxin stimulation of Toll-like receptor 4 (TLR4) resulting in an ameliorated response after subsequent re… 
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