Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells.

@article{Hermans2003SignalingMC,
  title={Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells.},
  author={Mirjam H. A. Hermans and Gert-Jan M. van de Geijn and Claudia Heijmans Antonissen and Judith Gits and Daphne van Leeuwen and Alister C Ward and Ivo P. Touw},
  journal={Blood},
  year={2003},
  volume={101 7},
  pages={2584-90}
}
Granulocyte colony-stimulating factor (G-CSF) is the major regulator of neutrophil production. Studies in cell lines have established that conserved tyrosines Tyr704, Tyr729, Tyr744, Tyr764 within the cytoplasmic domain of G-CSF receptor (G-CSF-R) contribute significantly to G-CSF-induced proliferation, differentiation, and cell survival. However, it is unclear whether these tyrosines are equally important under more physiologic conditions. Here, we investigated how individual G-CSF-R tyrosines… CONTINUE READING

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