Signaling mechanism of TGF-beta1-induced collagen contraction mediated by bovine trabecular meshwork cells.

@article{Nakamura2002SignalingMO,
  title={Signaling mechanism of TGF-beta1-induced collagen contraction mediated by bovine trabecular meshwork cells.},
  author={Yoshikuni Nakamura and Shinji Hirano and Katsuyoshi Suzuki and Keisuke Seki and Takeshi Sagara and Teruo Nishida},
  journal={Investigative ophthalmology & visual science},
  year={2002},
  volume={43 11},
  pages={
          3465-72
        }
}
PURPOSE To characterize the intracellular signaling mechanism that underlies the contraction of trabecular meshwork (TM) tissue. METHODS The contraction of collagen mediated by bovine TM cells was evaluated by measuring changes in the diameter of collagen gels in which the cells were embedded. Changes in the organization of the actin cytoskeleton were examined by laser-scanning confocal microscopy of cells stained with fluorescent phalloidin. Cell motility was monitored by time-lapse video… CONTINUE READING

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