Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.

@article{Menard2014SignalingLA,
  title={Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.},
  author={Laurence Menard and Tineke Cantaert and Nicolas Chamberlain and Stuart G Tangye and Sean D Riminton and Joseph A. Church and Amy D Klion and Charlotte Cunningham-Rundles and Kim E Nichols and Eric Meffre},
  journal={The Journal of allergy and clinical immunology},
  year={2014},
  volume={133 4},
  pages={1149-61}
}
BACKGROUND Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) can mediate the function of SLAM molecules, which have been proposed to be involved in the development of autoimmunity in mice. OBJECTIVE We sought to determine whether the SLAM/SAP pathway regulates the establishment of human B-cell tolerance and what mechanisms of B-cell tolerance could be affected by SAP deficiency. METHODS We tested the reactivity of antibodies isolated from single B cells from SAP… CONTINUE READING

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