Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns.

@article{Garca2001SignalingLA,
  title={Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns.},
  author={Ver{\'o}nica Edith Garc{\'i}a and Maria Florencia Quiroga and Maria Teresa Ochoa and Laura Ochoa and Virginia Pasquinelli and Leonardo Fainboim and Liliana M. Olivares and Raul Valdez and Daniel O. Sordelli and Gregorio Aversa and Robert L Modlin and Peter Allan Sieling},
  journal={Journal of immunology},
  year={2001},
  volume={167 10},
  pages={5719-24}
}
Induction of Th1 cytokines, those associated with cell-mediated immunity, is critical for host defense against infection by intracellular pathogens, including mycobacteria. Signaling lymphocytic activation molecule (SLAM, CD150) is a transmembrane protein expressed on lymphocytes that promotes T cell proliferation and IFN-gamma production. The expression and role of SLAM in human infectious disease were investigated using leprosy as a model. We found that SLAM mRNA and protein were more… CONTINUE READING

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