Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry.

@article{Hinsby2003SignalingIB,
  title={Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry.},
  author={Anders M\orkeberg Hinsby and Jesper V. Olsen and Keiryn L. Bennett and Matthias Mann},
  journal={Molecular & cellular proteomics : MCP},
  year={2003},
  volume={2 1},
  pages={29-36}
}
Overexpression of the fibroblast growth factor receptor-1 (FGFR-1), a prototypic receptor tyrosine kinase, is a feature of several human tumors. In human 293 cells overexpression of the FGFR-1 leads to constitutive activation of the receptor with concomitant sustained high increase in the cellular level of phosphotyrosine-containing proteins. Here we use mass spectrometry to study the tyrosine-phosphorylated proteins induced by overexpression of the FGFR-1. Several well known components of FGFR… CONTINUE READING

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