Signaling in stem cell niches: lessons from the Drosophila germline.

@article{Yamashita2005SignalingIS,
  title={Signaling in stem cell niches: lessons from the Drosophila germline.},
  author={Yukiko M Yamashita and Margaret T Fuller and D Leanne Jones},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 4},
  pages={
          665-72
        }
}
Stem cells are cells that, upon division, can produce new stem cells as well as daughter cells that initiate differentiation along a specific lineage. Studies using the Drosophila germline as a model system have demonstrated that signaling from the stem cell niche plays a crucial role in controlling stem cell behavior. Surrounding support cells secrete growth factors that activate signaling within adjacent stem cells to specify stem cell self-renewal and block differentiation. In addition, cell… CONTINUE READING

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