Signaling in and regulation of ionizing radiation-induced apoptosis in endothelial cells.

Abstract

Exposure of mammalian cells to ionizing radiation leads primarily to DNA damage-induced cell death. The induction of apoptosis by ionizing radiation represents an alternative mode to cell kill. Breakdown of sphingomyelin to produce ceramide by activation of sphingomyelinase is one of the upstream signalling cascades activated in apoptotic cells in response… (More)

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