Corpus ID: 18223202

Signaling in Ovarian Cancer β Factor-That Contribute to the Inhibition of Transforming Growth Expression Profiling Identifies Altered Expression of Genes

@inproceedings{Sunde2006SignalingIO,
  title={Signaling in Ovarian Cancer $\beta$ Factor-That Contribute to the Inhibition of Transforming Growth Expression Profiling Identifies Altered Expression of Genes},
  author={Jan Sunde and H. Donninger and Kongming Wu and Michael E. Johnson and R. Pestell and G. Rose and S. Mok and J. Brady and T. Bonome and M. Birrer},
  year={2006}
}
Ovarian cancer is resistant to the antiproliferative effects of transforming growth factor-B (TGF-B); however, the mechanism of this resistance remains unclear. We used oligonucleotide arrays to profile 37 undissected, 68 microdissected advanced-stage, and 14 microdissected early-stage papillary serous cancers to identify signaling pathways involved in ovarian cancer. A total of seven genes involved in TGF-B signaling were identified that had altered expression >1.5-fold (P < 0.001) in the… Expand

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