Signaling in Channel/Enzyme Multimers ATPase Transitions in SUR Module Gate ATP-Sensitive K+ Conductance

@article{Zingman2001SignalingIC,
  title={Signaling in Channel/Enzyme Multimers ATPase Transitions in SUR Module Gate ATP-Sensitive K+ Conductance},
  author={Leonid V. Zingman and Alexey Alekseev and Martin Bienengraeber and Denice M. Hodgson and Amy B. Karger and Petras P. Dzeja and Andre Terzic},
  journal={Neuron},
  year={2001},
  volume={31},
  pages={233-245}
}
ATP-sensitive potassium (K(ATP)) channels are bifunctional multimers assembled by an ion conductor and a sulfonylurea receptor (SUR) ATPase. Sensitive to ATP/ADP, K(ATP) channels are vital metabolic sensors. However, channel regulation by competitive ATP/ADP binding would require oscillations in intracellular nucleotides incompatible with cell survival. We found that channel behavior is determined by the ATPase-driven engagement of SUR into discrete conformations. Capture of the SUR catalytic… CONTINUE READING