Signaling function of alpha-catenin in microtubule regulation.

  title={Signaling function of alpha-catenin in microtubule regulation.},
  author={Michael Shtutman and Alexander Chausovsky and Masha Prager-Khoutorsky and Natalia Schiefermeier and Shlomit K. Boguslavsky and Zvi Kam and Elaine Fuchs and Benjamin Geiger and Gary G. Borisy and Alexander D Bershadsky},
  journal={Cell cycle},
  volume={7 15},
Centrosomes control microtubule dynamics in many cell types, and their removal from the cytoplasm leads to a shift from dynamic instability to treadmilling behavior and to a dramatic decrease of microtubule mass (Rodionov et al., 1999; PNAS 96:115). In cadherin-expressing cells, these effects can be reversed:non-centrosomal cytoplasts that form cadherin-mediated adherens junctions display dense arrays of microtubules (Chausovsky et al., 2000; Nature Cell Biol 2:797). In adherens junctions… CONTINUE READING
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