Signaling from endosomes: location makes a difference.

  title={Signaling from endosomes: location makes a difference.},
  author={Lukasz Sadowski and Iwona Pilecka and Marta Miaczynska},
  journal={Experimental cell research},
  volume={315 9},
In all transmembrane receptor systems the kinetics of receptor trafficking upon ligand stimulation is maintained in a balance between degradative and recycling pathways in order to keep homeostasis and to strictly control receptor-mediated signaling. Endocytosis is commonly considered as an efficient mechanism of uptake and transport of membrane-associated signaling molecules leading to attenuation of ligand-induced responses. Accumulating evidence, however, shows that signaling from… CONTINUE READING