Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4

@inproceedings{Richter2008SignalingF,
  title={Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4},
  author={Wito Richter and Peter Day and Rani Agrawal and Matthew D Bruss and S. Granier and Yvonne L. Wang and S\oren G. F. Rasmussen and Kathleen Horner and Ping F. Wang and Tao Lei and Andrew J. Patterson and Brian K. Kobilka and M. P{\'e}rez-D{\'i}az Conti},
  booktitle={The EMBO journal},
  year={2008}
}
Beta1- and beta2-adrenergic receptors (betaARs) are highly homologous, yet they play clearly distinct roles in cardiac physiology and pathology. Myocyte contraction, for instance, is readily stimulated by beta1AR but not beta2AR signaling, and chronic stimulation of the two receptors has opposing effects on myocyte apoptosis and cell survival. Differences in the assembly of macromolecular signaling complexes may explain the distinct biological outcomes. Here, we demonstrate that beta1AR forms a… CONTINUE READING