Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide.

@article{Latorre2003SignalingEM,
  title={Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide.},
  author={Eduardo Latorre and M Pilar Collado and Inmaculada Fern{\'a}ndez and M. Dolores Aragon{\'e}s and R. Edgardo Catalan},
  journal={European journal of biochemistry},
  year={2003},
  volume={270 1},
  pages={
          36-46
        }
}
Ceramide is a lipid second messenger that acts on multiple-target enzymes, some of which are involved in other signal-transduction systems. We have previously demonstrated that endogenous ceramide modifies the metabolism of brain ethanolamine plasmalogens. The mechanism involved was studied. On the basis of measurements of breakdown products, specific inhibitor effects, and previous findings, we suggest that a plasmalogen-selective phospholipase A2 is the ceramide target. Arachidonate-rich… CONTINUE READING