Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor.

  title={Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor.},
  author={Keiko Okuda and Rosemary Foster and James D Griffin},
  journal={Annals of the New York Academy of Sciences},
  pages={305-12; discussion 312-3}
The granulocyte/macrophage colony-stimulating factor (GM-CSF)/interleukin-3 (IL-3)/IL-5 receptors are a family of heterodimeric transmembrane proteins expressed by myeloid lineage cells. Each receptor has a unique ligand-binding alpha chain and they share a common beta chain (beta c chain). Binding of GM-CSF activates at least one receptor-associated tyrosine kinase, JAK2, and rapidly induces tyrosine phosphorylation of the GMR beta c chain (GMR beta), but not the GMR alpha chain (GMR alpha… CONTINUE READING

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