Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization.

Abstract

BACKGROUND Although PAK1 regulates cytoskeleton and microtubule dynamics, its role in controlling the functions of MCAK remains unknown. RESULTS PAK1 phosphorylates MCAK and thereby regulates both its localization and function. CONCLUSION MCAK is a cognate substrate of PAK1. SIGNIFICANCE This study provides a novel mechanistic insight into PAK1… (More)
DOI: 10.1074/jbc.M112.399576

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@article{Pakala2012SignalingdependentPO, title={Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization.}, author={Suresh Babu Pakala and Vasudha S. Nair and Sirigiri DivijendraNatha Reddy and Rakesh Kumar}, journal={The Journal of biological chemistry}, year={2012}, volume={287 48}, pages={40560-9} }