Signaling defects in T lymphocytes of patients with malignancy

Abstract

In patients with cancer, alterations in the expression of T-cell receptor-associated molecules in tumor-infiltrating lymphocytes (TIL) as well as in circulating lymphocytes have been reported. By quantitative flow cytometry analysis, decreased or absent expression of the ζ chain in CD4+ or CD8+ T cells as well as in natural killer (NK) cells was… (More)
DOI: 10.1007/s002620050585

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