Signaling defects and functional impairment in T-cells from cervical cancer patients.

@article{Cheriyan2009SignalingDA,
  title={Signaling defects and functional impairment in T-cells from cervical cancer patients.},
  author={Vino T. Cheriyan and Smriti Murali Krishna and Aswin Kumar and Puthuveetil Govindan Jayaprakash and Prabha Balaram},
  journal={Cancer biotherapy & radiopharmaceuticals},
  year={2009},
  volume={24 6},
  pages={
          667-73
        }
}
The ability of T-lymphocytes to recognize antigens and transduce signals to the nucleus successfully is a key component in the initiation and maintenance of an immune response. The present study addressed the expression status of the signal-transducing proteins in relation to the immune impairment in cervical cancer patients. Immune response was measured by evaluating lymphocyte subpopulations CD3(+), CD4(+), and CD8(+), using flowcytometry, natural killer cell activity, using the single-cell… CONTINUE READING
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