Signaling crosstalk underlying synergistic induction of astrocyte differentiation by BMPs and IL-6 family of cytokines.

@article{Yanagisawa2001SignalingCU,
  title={Signaling crosstalk underlying synergistic induction of astrocyte differentiation by BMPs and IL-6 family of cytokines.},
  author={Masamitsu Yanagisawa and Kinichi Nakashima and Takumi Takizawa and Wataru Ochiai and Hiroufmi Arakawa and Tetsuya Taga},
  journal={FEBS letters},
  year={2001},
  volume={489 2-3},
  pages={
          139-43
        }
}
We here show that bone morphogenetic protein (BMP) 7 acted in synergy with the distinct type of cytokines, leukemia inhibitory factor (LIF) and interleukin (IL) 6 that are in the IL-6 family, to induce astrocyte differentiation from neuroepithelial cells as assessed by expression of glial fibrillary acidic protein (GFAP). In this synergistic action, transcription factors, Smads and STAT3 (for signal transducer and activator of transcription 3) activated by respective group of cytokines, as well… CONTINUE READING
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