Signaling cross-talk in the resistance to HER family receptor targeted therapy

  title={Signaling cross-talk in the resistance to HER family receptor targeted therapy},
  author={Hideki Yamaguchi and Shaohua Chang and James Leigh Hsu and M C Hung},
Epidermal growth factor receptor (EGFR) and human EGFR 2 (HER2) have an important role in the initiation and progression of various types of cancer. Inhibitors targeting these receptor tyrosine kinases are some of the most successful targeted anticancer drugs widely used for cancer treatment; however, cancer cells have mechanisms of intrinsic and acquired drug resistance that pose as major obstacles in drug efficacy. Extensive studies from both clinical and laboratory research have identified… CONTINUE READING
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