Signaling cross talk between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in pancreatic islet β-cells.

@article{Ma2011SignalingCT,
  title={Signaling cross talk between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in pancreatic islet β-cells.},
  author={Fanxin Ma and Zhe Wei and Chunwei Shi and Yan Jun Gan and Jia Lu and Stuart J. Frank and James Balducci and Y. S. Huang},
  journal={Molecular endocrinology},
  year={2011},
  volume={25 12},
  pages={
          2119-33
        }
}
Dysfunction and destruction of pancreatic islet β-cells is a hallmark of diabetes. Better understanding of cell signals regulating β-cell growth and antiapoptosis will allow development of therapeutic strategies for diabetes by preservation and expansion of β-cell mass. GH and IGF-I share a complicated physiological relationship and have both been implicated in β-cell function. GH and IGF-I exert their biological effects through binding to respective receptors (GHR and IGF-IR) and subsequently… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 65 REFERENCES

Cell lines derived from pancreatic islets

  • Molecular and Cellular Endocrinology
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL