Signaling components involved in leptin-induced amplification of the atherosclerosis-related properties of human monocytes.

@article{Konstantinidis2009SignalingCI,
  title={Signaling components involved in leptin-induced amplification of the atherosclerosis-related properties of human monocytes.},
  author={Diamantis Konstantinidis and Konstantinos Paletas and George Koliakos and Martha Kaloyianni},
  journal={Journal of vascular research},
  year={2009},
  volume={46 3},
  pages={199-208}
}
BACKGROUND/AIMS Leptin, a 16-kDa cytokine that is released mainly by the adipose tissue, is known to affect a wide assortment of processes, ranging from energy homeostasis to angiogenesis and the immune response. In the present study, the effect of leptin on atherosclerosis-related properties of human monocytes was investigated. methods: Monocytes were isolated from whole blood obtained from healthy donors who had normal body mass index values. Pharmacological inhibition of specific signaling… CONTINUE READING
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