Signaling complexes of voltage-gated calcium channels and G protein-coupled receptors.

@article{Altier2008SignalingCO,
  title={Signaling complexes of voltage-gated calcium channels and G protein-coupled receptors.},
  author={Christophe Altier and Gerald W Zamponi},
  journal={Journal of receptor and signal transduction research},
  year={2008},
  volume={28 1-2},
  pages={71-81}
}
Activation of opioid or opioid-receptor-like (ORL1 a.k.a. NOP or orphanin FQ) receptors mediates analgesia through inhibition of N-type calcium channels in dorsal root ganglion (DRG) neurons (1, 2). Unlike the three types of classical mu, delta, and kappa opioid receptors, ORL1 mediates an agonist-independent inhibition of N-type calcium channels. This is mediated via the formation of a physical protein complex between the receptor and the channel, which in turn allows the channel to… CONTINUE READING