Signaling can be uncoupled from imaging of the somatostatin receptor type 2.

@article{Han2007SignalingCB,
  title={Signaling can be uncoupled from imaging of the somatostatin receptor type 2.},
  author={Lin Han and Dan Yang and Vikas Kundra},
  journal={Molecular imaging},
  year={2007},
  volume={6 6},
  pages={427-37}
}
Endogenous and exogenous somatostatin receptors are commonly targeted for imaging using radiopharmaceutical analogues of somatostatin. Ligand binding activates receptor-mediated signaling. We assessed whether somatostatin receptor type 2A (SSTR2A) imaging can be uncoupled from signal transduction. In both human fibrosarcoma (HT1080) and human embryonic kidney (HEK293) cells, reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay found similar levels of expression… CONTINUE READING