Signaling by retinol and its serum binding protein.

  title={Signaling by retinol and its serum binding protein.},
  author={Noa Noy},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP) which, in turn, associates with transthyretin (TTR) to form a retinol-RBP-TTR ternary complex. At some tissues, retinol-bound (holo-) RBP is recognized by a membrane protein termed STRA6, which transports retinol from extracellular RBP into cells and, concomitantly, activates a JAK2/STAT3/5 signaling cascade that culminates in induction of STAT target genes. STRA6-mediated retinol transport and cell signaling are… CONTINUE READING
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