Signaling by a non-dissociated complex of G protein βγ and α subunits stimulated by a receptor-independent activator of G protein signaling, AGS8.

@article{Yuan2007SignalingBA,
  title={Signaling by a non-dissociated complex of G protein βγ and α subunits stimulated by a receptor-independent activator of G protein signaling, AGS8.},
  author={Chujun Yuan and Motohiko Sato and Stephen M. Lanier and Alan V. Smrcka},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 27},
  pages={19938-47}
}
Accumulating evidence suggests that heterotrimeric G protein activation may not require G protein subunit dissociation. Results presented here provide evidence for a subunit dissociation-independent mechanism for G protein activation by a receptor-independent activator of G protein signaling, AGS8. AGS8 is a member of the AGS group III family of AGS proteins thought to activate G protein signaling primarily through interactions with Gbetagamma subunits. Results are presented demonstrating that… CONTINUE READING

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