Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.

  title={Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.},
  author={Zvi Naor},
  journal={Frontiers in neuroendocrinology},
  volume={30 1},
Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH analogs are extensively used in in vitro fertilization, and treatment of sex hormone-dependent cancers, due to their ability to bring about 'chemical castration'. The interaction of GnRH with its cognate type I receptor (GnRHR) in pituitary gonadotropes results in the activation of Gq/G(11), phospholipase Cbeta (PLCbetaI), PLA(2), and PLD. Sequential activation of the phospholipases generates the second… CONTINUE READING
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