Signaling by ATP receptors in astrocytes.

  title={Signaling by ATP receptors in astrocytes.},
  author={Joseph T. Neary and Qiang Zhu},
  volume={5 13},
Treatment of primary cultures of rat cerebral cortical astrocytes with extracellular ATP caused a 3- to 4-fold stimulation of mitogen-activated protein (MAP) kinase activity. Studies with agonists and antagonists of P1 and P2 purinergic receptors indicated that this activation is mediated by ATP/P2 purinergic receptors rather than adenosine/P1 purinergic receptors. Increased cAMP levels did not significantly inhibit the activation of MAP kinase by ATP but did inhibit the stimulation of MAP… CONTINUE READING