Signaling between the placenta and the uterus involving the mitogen-regulated protein/proliferins.

  title={Signaling between the placenta and the uterus involving the mitogen-regulated protein/proliferins.},
  author={Y. Q. Fang and Pierig Lepont and John T. Fassett and Stephen P. Ford and Adnan M. D. Mubaidin and Richard T. Hamilton and Marit Nilsen-Hamilton},
  volume={140 11},
The aim of this investigation was to examine signaling between the placenta and uterus during pregnancy. To do this, we determined the tissue messenger RNA and protein levels of members of a glycopeptide hormone family known to stimulate the proliferation of uterine cells and related these levels to the growth of the uterus during pregnancy in the mouse. This hormone family is known as mitogen-regulated protein (MRP); alternatively proliferin (PLF). Three mrp/plf genes, plf1, mrp3 and mrp4, are… 
Roles of the mitogen-induced proteins, mitogen regulated protein/proliferin and 24p3/uterocalin, during mouse development
The profiles of the wet weight and DNA content of the uterus were characterized and found to have a positive correlation with the expression profile of MRP/PLFs, which are thought to stimulate angiogenesis in the placenta and the uterus, and stimulate uterine cell growth during mid-gestation.
Mrp4, a new mitogen-regulated protein/proliferin gene; unique in this gene family for its expression in the adult mouse tail and ear.
Unique among the members of the mrp/plf family for its expression in the hair follicles of the tail and ear, MRP4 is expected to have a singular role in the growth and development of these follicles.
Roles of prolactin and related members of the prolactin/growth hormone/placental lactogen family in angiogenesis.
The known and speculative issues underlying the effects of the prolactin, growth hormone and placental lactogen family of proteins on angiogenesis are summarized, and important remaining enigmas in this field of research are addressed.
Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus
Bioinformatic analysis of upstream regulatory regions identified conserved combinations of putative transcription factor binding sites shared by genes expressed in the same trophoblast subtype, supporting the notion that local regulatory elements, rather than locus control regions, specify subtype-specific expression.
High expression in involuting reproductive tissues of uterocalin/24p3, a lipocalin and acute phase protein.
It is proposed that the role of uterocalin during involution is to provide a window of time during which resident cells are protected from the degradative enzymes, free radicals and other secreted products of activated phagocytes to allow these cells to prepare to survive the processes of involution.
Mrp3, a mitogen-regulated protein/proliferin gene expressed in wound healing and in hair follicles.
It is demonstrated that Mrp3 is induced in wound edge keratinocytes during cutaneous wound healing and also temporally appears in the outer root sheath of the hair follicle during the late anagen phase of thehair cycle.
Mitogen‐regulated protein/proliferin mRNA induction following single applications of tumor promoters to murine skin
It is demonstrated that mrp/plf‐mRNA is differentially expressed in murine skin in response to mechanistically distinct tumor promoters and has potential utility as a short‐term biomarker for tumor promoting effects in chemical carcinogenesis.
Do molecular signals from the conceptus influence endometrium decidualization in rodents?
  • J. Herington, B. Bany
  • Biology
    Journal of experimental zoology. Part B, Molecular and developmental evolution
  • 2009
Data is reviewed that support the hypothesis that paracrine signals from the rodent conceptus influence decidualization and are compared and contrasted with information currently known in other species that exhibit different implantation modes.
Benzopyrene and Experimental Stressors Cause Compensatory Differentiation in Placental Trophoblast Stem Cells
This review enumerates and analyzes recent reports on the effects of benzopyrene on placental function in terms of the emerging paradigm that placental differentiation from stem cells can be regulated when insufficient production of stem cells is caused by stress.
Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice
It is demonstrated that PLF-1 can improve skeletal muscle repair in response to injury, possibly via the modulation of inflammation and proliferation and regeneration, suggesting a novel therapeutic strategy for the management of skeletal muscle diseases.