Signaling between the Placenta and the Uterus Involving the Mitogen-Regulated Protein/Proliferins1.

@article{Fang1999SignalingBT,
  title={Signaling between the Placenta and the Uterus Involving the Mitogen-Regulated Protein/Proliferins1.},
  author={Yu Fang and Pierig Lepont and John T Fassett and Stephen P. Ford and Adnan M. D. Mubaidin and Richard T. Hamilton and Marit Nilsen-Hamilton},
  journal={Endocrinology},
  year={1999},
  volume={140 11},
  pages={5239-5249}
}
The aim of this investigation was to examine signaling between the placenta and uterus during pregnancy. To do this, we determined the tissue messenger RNA and protein levels of members of a glycopeptide hormone family known to stimulate the proliferation of uterine cells and related these levels to the growth of the uterus during pregnancy in the mouse. This hormone family is known as mitogen-regulated protein (MRP); alternatively proliferin (PLF). Three mrp/plf genes, plf1, mrp3 and mrp4, are… 
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It seems that MRP/PLF is a placentally derived growth factor, which stimulates proliferation in the uterus in a developmentally defined period to coordinate uterine growth with fetal development.
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