Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling.

@article{Nastase2017SignalingAT,
  title={Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling.},
  author={Madalina-Viviana Nastase and Andrea Janicova and Malgorzata Wygrecka and Liliana Schaefer},
  journal={Antioxidants & redox signaling},
  year={2017},
  volume={27 12},
  pages={
          855-873
        }
}
SIGNIFICANCE Proteoglycans (PGs), besides their structural contribution, have emerged as dynamic components that mediate a multitude of cellular events. The various roles of PGs are attributed to their structure, spatial localization, and ability to act as ligands and receptors. Reactive oxygen species (ROS) are small mediators that are generated in physiological and pathological conditions. Besides their reactivity and ability to induce oxidative stress, a growing body of data suggests that… CONTINUE READING
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