Signaling angiogenesis via p42/p44 MAP kinase and hypoxia.

  title={Signaling angiogenesis via p42/p44 MAP kinase and hypoxia.},
  author={Edurne Berra and Julie Milanini and Darren E. Richard and Maude Le Gall and Francesc Vi{\~n}als and Emmanuel Gothi{\'e} and Dani{\`e}le Roux and Gilles Pag{\'e}s and Jacques M. Pouyssegur},
  journal={Biochemical pharmacology},
  volume={60 8},
Angiogenesis is associated with a number of pathological situations. In this study, we have focused our attention on the role of p42/p44 MAP (mitogen-activated protein) kinases and hypoxia in the control of angiogenesis. We demonstrate that p42/p44 MAP kinases play a pivotal role in angiogenesis by exerting a determinant action at three levels: i) persistent activation of p42/p44 MAP kinases abrogates apoptosis; ii) p42/p44 MAP kinase activity is critical for controlling proliferation and… CONTINUE READING

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