Signaling and function of insulin-like peptides in insects.

  title={Signaling and function of insulin-like peptides in insects.},
  author={Qi Hui Wu and Mark R. Brown},
  journal={Annual review of entomology},
Insulin-like peptides (ILPs) exist in insects and are encoded by multigene families that are expressed in the brain and other tissues. Upon secretion, these peptides likely serve as hormones, neurotransmitters, and growth factors, but to date, few direct functions have been demonstrated. In Drosophila melanogaster, molecular genetic studies have revealed elements of a conserved insulin signaling pathway, and as in other animal models, it appears to play a key role in metabolism, growth… CONTINUE READING