Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium.

@article{Roach2008SignalingAC,
  title={Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium.},
  author={Tamara I. Roach and Robert A. Rebres and Iain D C Fraser and Dianne L Decamp and Keng-mean Lin and Paul C. Sternweis and Mel I. Simon and William E. Seaman},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 25},
  pages={
          17351-61
        }
}
  • Tamara I. Roach, Robert A. Rebres, +5 authors William E. Seaman
  • Published in
    The Journal of biological…
    2008
  • Biology, Medicine
  • Studies in fibroblasts, neurons, and platelets have demonstrated the integration of signals from different G protein-coupled receptors (GPCRs) in raising intracellular free Ca(2+). To study signal integration in macrophages, we screened RAW264.7 cells and bone marrow-derived macrophages (BMDM) for their Ca(2+) response to GPCR ligands. We found a synergistic response to complement component 5a (C5a) in combination with uridine 5'-diphosphate (UDP), platelet activating factor (PAF), or… CONTINUE READING

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