Signaling and Regulation miR-31 Is a Broad Regulator of b 1-Integrin Expression and Function in Cancer Cells

@inproceedings{Augoff2011SignalingAR,
  title={Signaling and Regulation miR-31 Is a Broad Regulator of b 1-Integrin Expression and Function in Cancer Cells},
  author={Katarzyna Augoff and Mitali Das and Katarzyna Bialkowska and Brian McCue and Edward F Plow and Khalid Sossey-Alaoui},
  year={2011}
}
Integrins are adhesion receptors involved in bidirectional signaling that are crucial for various cellular responses during normal homeostasis and pathologic conditions such as cancer progression and metastasis. Aberrant expression of noncoding microRNAs (miRNA) has been implicated in the deregulation of integrin expression and activity, leading to the development and progression of cancer tumors, including their acquisition of the metastatic phenotype. miR-31 is a key regulator of several… CONTINUE READING

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