Signaling and Regulation TheProto-oncogenePKC i Regulates the Alternative Splicing of Bcl-x Pre-mRNA

@inproceedings{Shultz2012SignalingAR,
  title={Signaling and Regulation TheProto-oncogenePKC i Regulates the Alternative Splicing of Bcl-x Pre-mRNA},
  author={Jacqueline C. Shultz and Ngoc Vu and Michael David Shultz and M U Mba and Brian A. Shapiro and Charles Edward Chalfant},
  year={2012}
}
Two splice variants derived from the Bcl-x gene via alternative 50 splice site selection (50SS) are proapoptotic Bcl-x(s) and antiapoptotic Bcl-x(L). Previously, our laboratory showed that apoptotic signaling pathways regulated the alternative 50SS selection via protein phosphatase-1 and de novo ceramide. In this study, we examined the elusive prosurvival… CONTINUE READING