Signaling and Regulation MicroRNA-30 c-2 Expressed in Ovarian Cancer Cells Suppresses Growth Factor – Induced Cellular Proliferation and Downregulates the Oncogene BCL 9

@inproceedings{Jia2011SignalingAR,
  title={Signaling and Regulation MicroRNA-30 c-2 Expressed in Ovarian Cancer Cells Suppresses Growth Factor – Induced Cellular Proliferation and Downregulates the Oncogene BCL 9},
  author={Wei Jia and Juliet O. Eneh and Supriya M. Ratnaparkhe and Molly K. Altman and Mandi M. Murph},
  year={2011}
}
MicroRNAs (miRNAs) are small noncoding RNAs that function as master regulators of posttranscriptional gene expression with each miRNA negatively regulating hundreds of genes. Lysophosphatidic acid (LPA) is a mitogenic lipid present within the ovarian tumor microenvironment and induces LPA receptor activation and intracellular signaling cascades like ERK/MAPK, leading to enhanced cellular proliferation. Here, we show that in SKOV-3 and OVCAR-3 cells, LPA stimulation at concentrations ranging… CONTINUE READING