Signaling active CD95 receptor molecules trigger co-translocation of inactive CD95 molecules into lipid rafts.

Abstract

The capability of soluble CD95L trimers to trigger CD95-associated signaling pathways is drastically increased by oligomerization. The latter can be achieved, for example, by antibodies recognizing a N-terminal epitope tag in recombinant CD95L variants or by genetic engineering-enforced formation of hexamers. Using highly sensitive and accurate binding… (More)
DOI: 10.1074/jbc.M111.328211

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